Tim-3 Directly Enhances CD8 T Cell
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Comment on "Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection".
T cell Ig and mucin domain (Tim) 3 is a surface molecule expressed throughout the immune system that can mediate both stimulatory and inhibitory effects. Previous studies have provided evidence that Tim-3 functions to enforce CD8 T cell exhaustion, a dysfunctional state associated with chronic stimulation. In contrast, the role of Tim-3 in the regulation of CD8 T cell responses to acute and tra...
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